Biological quality control is not a substitute for mechanical calibration using a 3L syringe. While BioQC involves testing a healthy staff member to track longitudinal stability, it cannot provide the NIST-traceable accuracy required for clinical diagnostics. You should perform BioQC at least once a week as a secondary safety net. This practice helps identify subtle sensor drifts that a standard daily syringe check might miss, providing an extra layer of clinical confidence.